Join the team that is delivering RNA to the world

Highlights of working here

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    Health Insurance

    Blue Cross Blue Shield plan with employer HSA contribution

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    Paid Time Off

    Unlimited PTO policy

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    Competitive Benefits

    Paid family and medical leave, disability, and life insurance

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    Develop cutting edge tech in the exciting new field of RNA

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    Help build a platform that ultimately serves patients in need

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    Watertown, MA

    Ideally located in Greater Boston’s burgeoning biotech hub

Ready to join the team?

Checkout out current openings

Senior Scientist I | Biochemistry

Watertown, MA

About the Role:

Your primary role as a Senior Scientist I – Biochemistry at EnPlusOne Biosciences is to help lead efforts in the laboratory to further advance the state of scaled enzymatic RNA oligonucleotide synthesis. You will support the “EnPlusOne Biology Engine” by managing protein expression/purification activities and improve platform capabilities through various molecular biology projects. You will play a critical role in developing an enzymatic synthesis pilot lab and leading the completion of key technological milestones. You will manage junior staff members and lead the creation of standard operating protocols for biochemistry and bioprocessing unit operations. You will work closely with chemists and engineers to optimize, troubleshoot, and develop various processes for the enzymatic synthesis platform. Additional responsibilities include thoroughly documenting experimental results and observations, preparing quality control reports, presenting research results, and contributing to any arising patent applications or publications. Successful candidates are motivated, curious, flexible, and able to collaborate and communicate in a multidisciplinary environment.


Basic Qualifications:

  • Advanced degree in a biological science or related field such as molecular biology, biochemistry, or bioprocess/biochemical engineering is required.
  • At least 5-8 years of wet lab technical or research experience, specifically relating to protein expression, purification, and characterization in the synthetic biology and oligonucleotide synthesis fields. A PhD may count towards years of experience.


Desired Technical Skills:

  • Expertise in oligonucleotide synthesis, nucleic acid chemistry and enzymatic kinetics/characterization
  • Excellent skills in molecular biology and related techniques such as PCR, qPCR, electrophoresis, & NGS
  • Demonstrated competency in bacterial plasmid design, transformation, cloning, and culturing
  • Expert at protein mutagenesis, expression, and purification techniques at mid- to large-scale
  • Hands-on experience with instrumental analysis via HPLC, LC/MS, MALDI-TOF, and FPLC
  • Experience with in vitro expression systems, assay development, bioconjugation techniques
  • Demonstrated ability for project management, digital record keeping, and maintenance of SOPs


Additional Qualifications:

  • Excellent problem-solving, analytical, protocol development and troubleshooting skills are required.
  • Ability to work well independently and to collaborate with a multidisciplinary group is essential.
  • Can lead projects and delegate specific tasks to junior team members, educating when necessary.
  • Should be highly motivated, detail oriented, organized, an initiative taker & effective communicator.
  • Able to present data and articulate findings to scientific community as well as internal stake holders.
  • Willing to participate in publishing of manuscripts and the filing of patents apps describing new IP


Perks of Working with Us:

  • The opportunity to work with a highly multidisciplinary and collaborative team, where there is plenty of room to learn and grow. We believe in performing solid science as well as transparency, truth, and healthy work environments.
  • Headquartered at 313 Pleasant St in Watertown, Massachusetts, USA, which is within a short distance to Watertown Square, Arsenal Yards, & Moody Street in Waltham.
  • Ample off-street parking in a private lot and biking accessibility via the Charles River Greenway. Public transportation can be accessed via the Watertown Connector (Harvard Square <> Watermills).
  • Competitive health insurance package, including dental, vision, and health savings account. Additional benefits include short and long-term disability insurance, paid family and medical leave insurance, and a 401(k)-retirement plan.


How to Apply:

  • Please send your resumé/CV and cover letter to